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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Kris Nicholas - but this handle made it very easy. I was a little worried that the plastic ...

    Makes painting a breeze! I bought this to help spray paint the under carriage/frame of my camping trailer. It was kind of a big spray painting job, but this handle made it very easy. I was a little worried that the plastic paint can holder might snap and break during the fitting and removing of the handle to the paint can. That didn't happen and it works great!

  • Resiree Boon - No. 1 in my 1st aid cabinet.

    This is my 1st time to write a review only because I totally believe in this product. I give this to my 3yo and 1.5yo kids at the onset of their viral infection (colds, cough or fever). This is very effective if given within the 1st few hours of symptoms and taken every few hours for maintenance. They may still have the symptoms but it wont be as bad or you may experience shortened sick days. This is a must-have in our home! I also take it at the first sign of symptoms and the virus wont push thru.

  • Bill - Product is NOT 18/10 stainless steel!

    While the written description clearly states that this product is made from 18/10 stainless steel, IT IS NOT.