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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Biblio-Nut - Beware 3rd party support posing as Kaspersky tech support

    I had a Kaspersky 2013 Internet Security Suite that stopped working. I agree with many viewers that trying to access live Kaspersky tech support can be an exercise in futility. However, given the huge number of complaints about Kaspersky tech support, you have to wonder if some reviewers made the same mistake I did, which was googling Kaspersky tech support and ending with a third party tech support firm. I had the unfortunate experience of dealing with a company called Guruaid.com. (phone:1-877-975-0566; they also have other phone numbers). I later found out that they are part of a company called Lester, Inc, headquartered in Connecticut, but with so called tech support from a center in India. Search guruaid.com and you will find a long list of complaints from unhappy and angry individuals who had the misfortune of accidentally contacting them.

  • Andrew M. Klein - Unimaginably Terrible!

    Dreadful, repetitive,childish, badly conceived waste of ink. Sucked in by other reviews and price, this set of three is my every worst reading experience so far in 2016.

  • Amazon Customer - One Inch long vitamin and the serving size is 3 pills

    I wish I could review this effectiveness of this vitamin, but they will never be taken at our house. Completely wasted money, so in the interest of giving others a heads up - The pills are one inch long ( yep, my daughter measured them) and you have to take THREE. I kept getting push back from my teens about how big they were, so tried to take one myself. They are huge and just gritty enough that they don't go down easily.