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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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    I haven't been able to find a bra I really like for years. Until now. I love this bra. VERY comfortable, looks great. It doesn't feel like I'm wearing a bra at all which is fantastic.

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    I've only been able to use a trial size from a hotel. Using the conditioner and shampoo together is fabulous! I have kinky curly hair (4b), and it leaves them soft moisturizer and shiny! I didn't wanna spend $10 on a bottle. but I might have too!

  • Nancy from Montana - This might be a very good product for most people but I'm dealing with acne ...

    This might be a very good product for most people but I'm dealing with acne scars and it doesn't seem to have helped much. I have used it faithfully morning and night since July 15 and haven't noticed much difference. Maybe it just takes longer for my type of skin.

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    I had what turned out to be toe fungus on my left big toe. I had lost the nail three or four times over a period of a few years. Each new nail would eventually "blister" at the base then crack and spit and loosen to the point of falling off. I finally did some web research and found some "hi-end" fancy named fungus treatments, all quite expensive. What I noticed is that they kept touting that they had "tree tea oil" in them. So I mused, this seems to be the magic curing ingredient these fancy treatments were depending on. I wondered if this tree tea oil was available on it own. Seems to me that this "tree tea oil" is the stuff I really need. Sure enough, it was available, and for a fraction of the price of the fancy names that "included" it. I ordered bottle and treated my toe diligently EVERY morning with the oil, applying it with a Q-tip for about two months, and it is now completely cured with a strong clear normal new nail. And I only used about 1/6 of the bottle to boot! My thoughts are, just use this inexpensive oil, with the key being; treating it consistently on a daily basis until one's nail grows back in normally and healthy again. :)

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