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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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Country: 184.173.128.237, North America, US

City: -77.4512 Virginia, United States

  • Andy Hdz - AWESOME WILL KEEP BUYING. DON'T THINK IS THE FAKE ONE

    I was dubious about this product based on the reviews that stated the product was fake. Fake or not, this was the first time I used it, and l fell in love. My hair dresser recommended to use it as my conditioner every other day, the results are amazing. I bleached my hair, and after trying many oils and other products to bring back the hydration to my hair, this product did what no other had done. I feel my hair soft and very manageable. Before buying this mask, I couldn't even comb my hair twice without getting knots. Of course my hair doesn't look the same as before I bleached it, but it has improved a lot!! I will keep buying it!

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    I want to love this game. The graphics are incredible. The game play is immersive. The storyline is engaging.

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    Great selection of short stories and very educational. Something you probably wouldn't come across in selective reading. I recommend this.