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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • jetteh22 - Large, bright and clear. Great monitor for the price.

    I bought this monitor to use as a second screen for my laptop when I am working in my home office. I plan to eventually purchase a new desktop and will get another one of these screens to create the dual-monitor experience I am looking for. I loved this screen so much that I am sure I'll get another just like it.

  • Anthony Y. - 90 4runner

    Working good so far, had a leak from somewhere near my thermostat, water pump, had leak, took it all apart and replaced and resealed, still leaked, poured this bottle in and no more leak and temps are prefect

  • Nancy J Quesenberry - Such a great program...well worth it!

    I had a little trouble getting this program to load...but I didn't give up. This is my 4th update to this program and worth every penny. My grandkids use it too. Makes wonderful cards that you can personalize too. I hated the year I didn't have this program.

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    Got to be one of the best games I've ever played and had. Also Amazon did not disappoint because my game was scheduled for a Monday but came almost a week early! Thank you Amazon!

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    The image is confusing. I ordered the detangler in the image with shea butter and that is not what I got. I got the one with not shea butter.

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    Because Science! Heh.. I have used CLR on toilets, shower-head, coffee pot, humidifier, rust stains... Excellent product. I just found a new use though;