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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Hippie - eh get what you pay for

    first couple of times the belt worked great , then started to dull out , changed batteries and it didnt help , i m going to save up for the real one thats 80 something

  • Julia - Best of luck

    I used this to try to pass a drug test for employment. (Medical) Marijuana user. No other drugs. Female, 5'6, 135 lbs, chronic daily smoker. Stopped using marijuana for about 9 days prior to drug test. Used this after two days of not smoking and tried an at-home drug test. Failed it. Used it for the real test after nine days of not smoking, failed it as well. Although my employers did not care, as I have medical reasons for use, they were unfortunately unable to hire me because they have to abide by federal laws rather than state. I followed the instructions EXACTLY. I chose this product because a male friend of mine has used it twice, both times successfully, to pass drug tests for employment. I'm thinking it works well with some people's bodies and not at all with others. If you're considering using it, try a practice run after at least 2 days of not using. If it doesn't work, ditch it and go another route. Best of luck!