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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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I had a main seal leak on my old Isuzu Trooper Diesel and was faced with an expensive repair just to fix a gasket. After searching around I saw a clip on youtube from a guy named Scotty something, recomending this. With it being a 2.8litre engine I bought 2 X 250ml bottles and poured it in the dipstick hole with a small funnel as Scotty did in the video. It took 2 days to completely reseal the gasket. Kept it in for one week then gave the car an oil and filter change. Been a few weeks now and still no drops of oil on my garage floor. Easiest fix ever
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