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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Amazon Customer - looks great works not so great

    not at all what I expected. all the write ups gave this product rave reviews. although it did heat up very quickly and I was able to use the steamer in under a minute, I was disappointed when i used it on my bathroom floor as it left very noticeable water spots after the floor dried. I'm no neat freak, but I couldn't stand seeing the spots so I went over the floor again and dried it with an old towel to prevent the water spots. I also tried the carpet feature to see how that worked. The micro fiber pad does have a tendency to roll up on you so you have to pay attention when using it in that capacity.

  • K. Slaback - Amazing! But, doesn't last

    I started looking for something like this when one of my kids (age 2) started waking at 4:30 thinking it was time to get up and play. Once I got him back in bed, around 5:00 my other kiddo (age 4) did the same thing. It was getting old, very quickly and I was beating myself up trying to explain to them why they need to stay in bed and how can they know it is okay to get up (without waking me up).