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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Patchypatchy - it was not working out too well and I saw this on amazon with good reviews. I got it on Monday

    My cat Gracie is 14 years old and was diagnosed with hyperthyroidism. The Vet prescribed medication and had the pharmacist create an cream to put on the inner part of her ears twice a day since it is very card to pill a cat. Anyway, it was not working out too well and I saw this on amazon with good reviews. I got it on Monday, although it was promised on Wednesday which is good. I thought my cat was near her end but after 2 days of this stuff she was her old self again. She is still skinny but not as ratty looking, but she has a good appetite so I think she will be okay.

  • Smartnoggin - No instructions. So disappointed!

    Was so excited to get my banana slicer in the mail, only to discover that the instructions were in Japanese. How was I supposed to cut my bananas without step by step directions?!?!? Are these people stupid? By the time I was sent the English version in the mail, all my bananas had turned brown and I was forced to throw them out. What a waste.