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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Kevnbro - Ticks Abound!

    I suppose customers who gave 5 stars for this product either have few ticks in their yards or none at all. Those of us living near tick infested woods however don't seem to be too terribly impressed with Bayer's new product. Our Australian Shepherd is covered with ticks daily even though he's been wearing his Seresto collar (we paid close to 80 bucks for) for close to a month. Almost a month in and we're already back to a topical tick treatment. I'd like my money back please.

  • Jonathan cudmore - It works, kind of.

    It does seem to work at reducing the need to shave but it does not completely remove the hair permanently. I had use it for over two years bought four refill cartridges as long as I used it weekly the hair did not come back. I stopped for three months and the hair did come back though there was less. I will continue to use.

  • Bobenny - Great Music

    This was a selection I made for a section of a fishing/hunting DVD I made for my husband & his friends of 20 years. Great in the fishing section. Love the music anyway.

  • R. Barrett - Good Book Some Details are debatable.

    Not A Bad Read But some of the facts are debatable.Read more than this book on DHEA to make an informed desision.

  • Joshua - Great Product. Practice tests are very helpful for getting ...

    Great Product. Practice tests are very helpful for getting down timing and strategies. I am going upgrade to Royal Flush Package to have video explanation to better understand each PAT strategy. It is awesome that the Software is always available (does't expire).

  • Melissa SonnoDelDrago - Better Call Saul meets Billions

    Goliath is like a cross between Showtime's "Billions" & AMC's "Better Call Saul", but darker. I really like Goliath. I started the first episode just before bed & now it's 6:30am and I'm on episode #6. Like Billy McBride, *I won't give up*. Totally bingeable series. In general I don't dig Billy Bob Thornton; I always absolutely love William Hurt. But Billy Bob shines in Goliath. And William Hurt is a beautiful monster; amazing as ever. Good job Amazon!