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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Heidi - Great case. Just a little more slippery than the ...

    Great case. Just a little more slippery than the same model I had for my iPhone 6 but not too bad. I'd still recommend :)

  • S. Langley - Used on bed sores & it worked.

    I give this 5 stars because I used it to wash my mom's bed sores and we noticed a difference the next day. However, after washing the sores, I also used an oil mixture of frankincense mixed with almond oil. The results were phenomenal. I still use it. When my son's feet/shoes start to smell, I make him wash his feet with this and we notice the odor goes away for quite some time.

  • R. Carlon - Tumbler may be ok, but junk lid ruins it.

    Tumbler may be ok, but junk lid ruins it by being way too loose. I ended up going to Walmart to look at the Ozark Trail ones to compare them and I'm sad to say that the Walmart brand blows them out of the water (so I bought two of those). The Ozark Trail feels more substantial, the quality control is better, and the warranty is a LIFETIME WARRANTY. That's better than Yeti and RTIC. After seeing that I'm not alone with the lid issues I'm questioning my prior plan to buy an RTIC cooler until they get their act together. This one is going back to fund buying more Ozark Trail tumblers.

  • Amazon Customer - Five Stars

    Probably the best version of PES I've played. The physics engine is much better than previous editions.