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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • chattykatty - Great stuff!!!

    I love Hair One Hair Cleanser and Conditioner with Jojoba - For Color-Treated Hair!!! My hair is very damaged from years of coloring. So I need help... I wasn't quite sold yet on the non-shampoo cleansing method until I tried this. I have fine hair. So I use 5 pumps per section of my head. Example: 5 on top, 5 on the right side, 5 on the left side and five in the back/nape area. Add a little extra water to "foam" it up. Pile my hair on top of my head and let it soak in 5-10 minutes. Rinse well then add my fave conditioner, leave that in a couple minutes and have my final rinse. That's it. Pretty easy. I've been using it for a week now and can tell a huge difference!!!!

  • Lauri Harman - Complete tax guide

    This is my reference guide for my tax business. I use it for backup research when I have questions I don't readily have the answers for. I have used this guide year after year and it has not let me down. Great guide to have on your shelf, it explains tax issues in easy to understand terms.

  • lisa - unknown

    hope it works as great as they say it does....we wont use till spring...on this product..till it warms up here in iowa