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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Purinton - I finally have my estate planning in order!

    After years of not having anything other than a will and beneficiaries selected for financial accounts I finally got around to putting together a comprehensive plan. Quicken Willmaker took me step by step through the process and seemed to be very thorough. Maybe a bit too thorough. Don't plan on sitting down for a half hour and getting this thing banged out. It helped me identify a part of my estate that would have had to go needlessly through probate. Also, I didn't really know how to put together a Health Care Directive or Durable Power of Attorney before using this program. I now have complete peace of mind with my estate planning. (I just hope it doesn't have to be utilized for a long time).

  • Heather Booker - My hands couldn't stop shaking!!

    Okay so I didnt buy this from amazon I got mine in Louisiana at walgreens. It was my first day taking them and I only took 2 around 1pm. I was drinking water all day and around 4pm I became very very very light headed and dizzy. Nonetheless I had To go to work. I couldn't stop my hands or even my whole body from shaking. I felt like I was about to just drop into a seizure at any moment! It is now 1:54 am and I still have the shakes! Though not as bad and I also have a slight headache. I'm not sure if it's just me but I wouldn't recommend these at all.