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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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Country: 69.30.245.206, North America, US

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  • Dana King - Very nice

    Most comfortable cycling/walking shoe I have had. Wider than many cycling shoes, which often seem narrow.Understated, cushioned. Ordered 47 and I am usually 11.5.

  • Nancy Davis - Not really what I expected

    Being a casual rider (about 10 miles a day, 6 days a week), this magazine seemed more geared toward longer, more professional riding. Very few articles were helpful to me.

  • Hilany - Malnourished - NO REFUND

    The shake, which is the bulk of this cleanse, not only tastes like rabbit food; it kept me light headed and forgetful throughout each day. The pills, which shouldn't be hard to swallow, reek like a chewed dog bone.

  • E. Rodriguez - Worst Product Ever

    Had my floors refinished, 2 months later we decided to clean the floor with Bona Floor Cleaner, What a huge mistake; it has totally damaged by floor, it left a film looks like water spots all over my house. I cannot remove it at all, the only way it will be removed according to a Flooring Specialist is by buffing out the entire house. I am very disappointed, stay far away from this product unless you want to pay the ultimate price A DAMAGED AND DULL FLOOR.