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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Paul K. - OK...IF you are planning to repaint

    If you are thinking that you can easily de-badge a vehicle with this stuff, think again. I was able to pretty easily remove the emblems with fishing line, but of course adhesive residue remained on the paint. No matter how long I let the adhesive remover sit on the residue, or how many times I saturated the area, it BARELY softened the adhesive. I took A LOT of elbow grease to remove the residue, and finally some of the clear coat and even a little of the color coat came off with it. Not a big deal if your planning to repaint, but a real problem if you are just planning to de-badge.

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    My husband and I have been taking this product for a long time. We love it !! Good for your heart and it gives