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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • S. Atwell - Should have believed the other reviewers

    This must be a problem with the seller but this is NOT the same quality of Biosilk that you would buy off the store shelves. Someone is diluting it & it is much more watery and has a thinner consistency. The smell is right but the results are NOT the same. Definitely NOT worth the savings. Better to buy from a real store & know you're getting the real deal. :(

  • Apingle - PLEASE READ...COMPLETE SNAKE OIL AND A SCAM!!!

    Now I've seen some slimey companies try to sell some cheap low-grade fish oil before but this product is just a straight old scam... plain and simple. If you go to the website of this product, omegaxl.com, they make it look all official and even include testimonials and a video from a doctor, BUT nowhere on the entire website does it show exactly how much omega 3 DHA & EPA are in the product. Omega 3 DHA & EPA are the two fatty acids in fish oil that has made fish oil such a big deal and has numerous benefits to your health. There are also other Omega fatty acids such as omega 6 & 9 but we get enough of those in our "western diet." Infact too much omega 6 has been linked to serious health problems because it CAUSES inflammation instead of preventing it like omega EPA does. That is why so many people on a "western diet" have serious inflammation related diseases in later years because most of our foods are just soaking in omega 6.

  • david l rist - Essential information

    Since the IRS no longer distributes Pub 17 this type of guide has become essential for people with complex tax returns, It is very well done, and should be, because of all the years of experience they have.