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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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Got this for a elderly family member for Christmas. Due to an injury suffered years ago, his lower body isn’t as mobile as he like it to be. His legs get tired out after about 10 minutes of exercise, but with the upper body motion he is able to continue to get at least 20-30 minutes a day of work out. He loves the walk thru design as its difficult for him to lift his legs over a traditional exercise bike. It took us around 40 minutes to assemble the bike, and really wasn’t too hard to figure out. The instructions weren’t great, but the images made it easy to assemble. There isn't much space to allocate to exercise equipment so this bike fit perfect in the allotted space. The bikes is easy to use as well as functional. Also not too much noise while in use. One thing I had to do was to place a bit of oil on the rotating handles in order to stop the squeaking sound, but that fixed the problem.
This is a great item. It does exactly what it says it does. The bananas come out the consistency of soft serve ice creams. I noticed many bad reviews b/c people thought it didn't taste like ice cream. Well, it's not supposed to taste like ice cream. It tastes like frozen bananas. I added dark chocolate chips for the kids and they loved it. Easy to clean, assemble and make. You do have to scape out the last bit after you open it, but no big deal. Would definitely recommend.