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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Adore - Not as great as I expected

    Not as great as I expected. Seems as though there are so many raves about this fertilizer but I was disappointed. I like that it is pet friendly, hated the smell. Did not notice any drastic change in my lawn. Worked better on my flowers.

  • Betsy Ross - Good Book

    I enjoyed this book very much. It arrived in great condition. I also picked up a few tidbits I did not know about the famous couple. A shame how fame and fortune affects talented stars.

  • Jessica Gambrel - I would still buy again - the price is great!

    The pills are a little large, so if you have issues taking pills, this will probably be an issue for you. They are bright yellow and I noticed after the first few days that my urine also started to look bright yellow. I would still buy again - the price is great!

  • Averagejoe - It really works!!!

    I was skeptical about this. My Brother told me about a similar product. Not sure it is the same. You just spray it on and leave it. Sounds too good to be true. I have some real heavy duty Green Mold on the north side of my house. I spayed it on yesterday and it did not seem to work at first but then it turned all the green stuff into a lite tan color. Now I guess when it rains the residue will wash away. I have to say that I am impressed. The stuff I used last year turned black and looked terrible. This stuff looks great.

  • Frank E. Tapper - Glad I did

    Had a 1st generation kindle , with no case. Bought the $50 kindle, so I chose this case to go with it. Glad I did. The kindle fits perfect in it. As the description states, it was made for the new kindle. It was not shipped with my kindle. Had to wait about a week to get it. Slow boat from China, I guess.

  • James F. Pettry - Doesn't work for everyone

    Tried to use this product on 3 different occasions, left it on for the specified duration the 1st time and it didn't remove any hair at all... so when attempting it the 2nd and 3rd time I left it on for longer than the instructions stated with still no results. Never felt the tingle or burning some reviewers mentioned