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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Vannessa Borrero - Hate It

    I ordered this book and ended up getting pages from the book, with hold punches on the side for a binder. Not what I was looking for.

  • Amazon Customer - Not for person with asthma, royal jelly!!

    I bought the greens, not for weight loss, just for the awesome benefits I was told about. More energy, would possibly help with my immune system and get rid of my constant sinusitis.. blah blah blah! I used it January 30th for the first time, 2 scoops in water. Later that day, I had anxiety SO BAD.. heart racing, couldn't breathe very well, was not feeling normal. I decided to try again in the 31st, but 1 scoop this time. Same thing, but over heating this time and I gained 3 pounds (just in 2 days). I read online about allergic reactions to this stuff. Finally came up with, royal jelly may cause allergic reaction for person with asthma. WHAT?! Why is this not on the label?? I have asthma, and worse case scenario is death. So if I had a HORRIBLE allergy to the royal jelly, I probably wouldn't be here right now. To top it off, I now have to pay $50 to cancel my 3 month loyal customer membership! I will NEVER buy another dietary product again. Lesson learned!