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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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I ordered this and lit it on front of my home, it is so much more clear and brighter than all the other laser lights I seen last year, I have a big home and if I wanted to cover whole house wouldn't have been so bright, ordered a second one and my home gets so well lit as well as my bushes out front looks like I stranded up lights also, excellent product, I even bought 2!!
I was excited to try this product as I know a person that is having success with it. I ordered the transformation kit, thinking I would go all in on the "challenge". I really enjoy the taste of their shakes. They make a good shake mix that tastes and smells like cake mix. I was able to mix these shakes with almond milk, sugar free jello mix, and powdered peanut butter to make a very tasty "butterfinger" shake that was only 180 calories. The shakes were never the problem.