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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • A.C. - Side effects

    I took this gradually, first one per day, then two, and then three which is the recommended dose. When I switched from two to three I got heartburn. I am sure it depends on the capsules because I had it for three mornings in a row, right after taking them, and usually I never have heartburn. I am going back to two or one for the rest of the two weeks and will be careful about the foods I take them with. I am not sure which ingredient caused this (if you do please leave a comment). As for the results, it's too early to tell and I guess it may be difficult anyway. I take these based on the combination of ingredients, which seems promising. Four stars.

  • Jessica V.Mitchell - Faulty. Not like they used to. False positives.

    First Response Early Response was my "go to" testing brand. For the past 3 months, I have also noticed these tests are not as great as they once were. I was positive at 6dpo with my son. A year and half ago.Now,I've noticed every month I take one its a false positive. I get a very faint line in the test line, a "squinter" and its not an evap,or indent because this shows up immediately as the urine passes. It even stays afterwards. All of them end up this way and even with a few days wait there is no progression!!! It is faulty. However,I then spent more money on other tests to confirm and negative. What happened to the stark white negatives, FRER? Over 4 boxes purchased and the same results each time,no matter which store I purchase these from and I'm not pregnant. Three stars for being a decent brand I trusted,but not as of late.