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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Linda Hall - Not what I was hoping for

    I really don't like to rate these type of things because what I like and what someone else likes are totally different. I am in my late 50's and have gained some weight since I quit smoking 3 years ago and was looking for something that would help me get back in shape. Sense I enjoyed dancing but hate exercise I thought this may be something I would enjoy. But, it's way too fast for me. It doesn't really teach you the moves like I was expecting. I've only used it a few times and plan on using it some more so maybe I will figure out how to learn the steps a little better. I've had a lot going on in the last few weeks though so it's been sitting kind of idle.

  • BabyJordyn11 - Worthless charger!

    Worst product I've purchased ever! Slots 1, 2, and 4 don't work and trying to get a replacement from this company sucks! Their charger makes batteries overheat and their shipping time from date of order to date of delivery took 6 days. Not worth it!!!!