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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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Country: 31.31.72.21, Europe, CZ

City: 14.4112 , Czechia

  • Monamin - This product is really amazing. I wanted to try the product for a ...

    This product is really amazing. I wanted to try the product for a while to see if it really works which it did. I had problems focussing after going through so much in the summer. I also had sleeping problems which was solved with this med. Weird but just take it from me. I would definitely purchase it again and this time in bulk. It's saving my grades.

  • Lynn - My laptop performed even worse than before the download

    I wish there was a place for no stars. I purchased PC Matic and kept it for two weeks. My laptop performed even worse than before the download. It was nearly impossible to get support. You have to email in your problem, and wait for a reply. They did respond to my first emails, but never with a fix. I kept emailing, and finally complained on their FB page. They replied that they were indeed responding - but for some strange reason I wasn't getting them. After two weeks of this, I got rid of PC Matic. I had gotten PC Matic due to all the favorable reviews, but subsequently discovered that the reason for this is that the company will provide free coverage for favorable reviews. One can get up to a year by writing them on various sites. I have AVG now and am very happy with the results.

  • Keith Dworak - Don't wait until it's too late

    I have a 15 year old septic tank and I never have it pumped. Instead, I pop one supply of RID-X into the toilet, flush it twice and then go to bed. Haven't had a problem yet! Make sure you follow the instructions and dont use a lot of water after you flush this, you want it to sit in your septic tank and not run into your yard. I just do it Friday night before bed and sleep in Saturday morning.