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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Mama Moon - Love It.

    Received a day early but I was excited to receive it. Sounds great for as cheap as it was. I still have my old flute from grade/high school but it's well beaten up. This is a welcome replacement and I absolutely love having a purple flute instead of my old faithful silver one. It's well worth the money.

  • Haydar KIR - It is not as big as I wanted (I am looking for something that is longer than what's advertised), but this actually worked out OK

    It is not as big as I wanted (I am looking for something that is longer than what's advertised), but this actually worked out just fine. The best part is that this is replacing the bath mat I had for less than 6 months without "anti-bacterial" coating. The old one looks terrible. I am hoping this will hold well for a long time. Other than that, it is nice to see a scrubber as a gift in the package. Nice touch. Definitely recommend.