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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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This program is lean, you never notice it bogging down your computer, which is very nice. You do have to go in an manually update it from time to time however to keep this lean functionality.
I have this program on 2 machines. Shared , I run windows xp 32 bit on both machines. The program seems to work as intended. It does have a problem with Outlook Sync as it does not auto attach as it should some emails and I have to attach them manualy.
I'm a guy and bought this instead of an electric razor because I get rashes if I shave too closely. Wow, this thing cuts through my thick beard like a pro. It's actually a pretty close shave! I like the hair on my throat to be cut down to the skin so I actually use the inexpensive Panasonic ES-SA40-K Pro Curve Wet/Dry Shaver push-up trimmers for that. I also love that the different sized guards that come with this allow me to trim body hair, my beard, side burns...it's awesome! Sorry if that's TMI but the guys out there need to know that this thing is far more practical, especially for the money, than a beard trimmer or even a much more expensive electric razor if you don't like a really close shave.
I've collected coins my whole life now im starting my 5 year old son on it. He loves the easy placement and that you can see both sides of the coin