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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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My cats chewed on this cable and now they can both speak. One of them is gay and the other wants to kill me. I would have rather not known.
I have really enjoyed this series so far. It's like a mix of horror and scifi at times. That being said this third book was ok. I feel like the ending of a war that has lasted for 50 years was a little anti-climatic and came a little to fast. The book was just a little to short to me given that it was the last book of a 3 book story arc. That being said I still enjoyed it for what it was.
Although Spore is initially quite impressive, given the novelty of such extensive use of user-designed content, the game quickly becomes disappointing. Creature design (vehicles and buildings also) is essentially cosmetic, aside from a few minor effects in one stage of the game. The game itself, rather than being a single, coherent experience, is divided into 5 mini games (stress on mini), each of which feels very incomplete. On the second or third time playing through, gameplay becomes very formulaic, like playing solitaire without shuffling. I never expect a game to live up to the hype (especially this much hype) but Spore doesn't even come close. Maybe Maxis plans to make us buy half a dozen expansions before the game is worth the base $50 price (see Sims).
This is the third time I've had to submit this review so its going to be shorter. I have used this product for 10 years. For the past 3 orders, the shampoo has been watered down.