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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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Country: 212.47.223.111, Europe, EE
City: 26 , Estonia
A few years back, some time in the late 80s, my late wife took it upon herself to destroy the house and steal most of my belongings, including my best pair of goose-down ear-warmers, and left leaving only a small note explaining why. I can't remember most of the details, but it mostly had to do with the dog, bless her heart, and her snoring. Unfortunately this drove me over the edge, seeing as how the dog died years ago. Searching the house, I came upon one small item she had neglected to take from me. My father's old microwave. Maybe it was because my parents burnt her favorite tea cozy, but never once had she appreciated them. I spent the next few days fiddling with the damn thing, eventually resorting to the burnt bits of macaroni and butter left over in the thing from my father's last microwave escapade in the 72. Using the last of my pocket change and a few bucks from the couch, I staggered to the store, starving, and bought a pack of smokes. I used to be fairly proficient in making fire with only a few scraps of paper, so I grabbed the nearest book and tore out a couple of pages. Luckily for me, sweet baby Jesus was smiling on me that day. But enough about me.
I just love reading a book set during the Christmas season when the weather is still warm. It puts me in the Christmas spirit, and that’s my favorite place to be! Since Debbie Macomber is one of my favorite “go to” authors, I always look forward to getting my hands on her book first. TWELVE DAYS OF CHRISTMAS: A Christmas Novel was an especially fun read. I adore the stories of Scrooge and “the Grinch” and watch the movies every year. Cain Maddox was a combination of both! It was an enchanting read – not to be missed this Christmas season!
This adapter works perfect with our 2012 BOB Revolution SE and Graco Snugride 30 car seat. It is very easy to put on. You have to remove it in order to fold the stroller down and that takes two hands. Slightly inconvenient when you are fussing with a car seat too, but well worth it!