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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • marie - Now i do not have to worry when im driving

    I work at a humane society and i am always driving dogs to vet appointments. Most of the dogs we have ride great in the car but we get a few that get very nervous in the car and move around a lot. I was looking for a way to keep them in one area of my car and i stumbled upon this OMore [2 Pack] Pet Safety Leads Car Vehicle Seat Belt Harness Seatbelt for Dogs/Cats, Nylon Material, 16-25 inch Adjustable - Black so i purchased it right away. This arrived quickly so i was able to use it the next time i had to transport a dog to the vet. I clicked it into my seat belt and then to the dog. I really really like that the length is adjustable so now matter what size dog you are using this for it will work. I used it for a bigger dog and it worked great. He stayed in my back seat and i had no issues with it. This is definitely a must for anyone who has dogs that ride in their car. This will definitely make your worries go away and keep any accidents from happening with the dogs that move a lot.

  • Doctore - I knew nothing...

    Out of all my engineering student friends I was the one people came to if they had an issue with excel or couldn't figure out how to do something. When I found this book in the library I peeked through it and realized. I knew nothing...

  • De Provence - Remington IPL6000

    I purchased this product with a little bit of hesitation as it is expensive but thought I would give it a try. I used it primarily on leg and arm hair. I have a fair complexion and brown hair which is supposedly ideal for the best results for this item. I read the directions so I would get the full benefits of the IPL. The IPL was small, nicely made and easy to use and wasn't painful even on the highest setting. I used it twice in 2 weeks as directed and was ready to use it for the third time. Upon turning the unit on the third time it did not chirp to indicate it was ready. I decided to return it since it was not working properly. Of course I did not get to see the benefits from prolonged use over time, but it did not seem to stop any hair from coming back in the spots that I used it on. They stated in the instruction booklet that you should see up to a 45% decrease in hair after just 2 uses. I did not see that result. I may have seen a 5% decrease but it is very difficult to say. Since the IPL wasn't working correctly and I was disappointed, I returned the unit for a refund.