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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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Country: 31.31.72.21, Europe, CZ

City: 14.4112 , Czechia

  • Erin Himmelmann - Excellent product!

    Design wise it's very streamlined and doesn't take up a lot of space. It opens up the wine and makes the flavor come out so much.

  • Retortnegid - Overrated and dangerous to the computer.

    Installed and ran Acronis True Image 2015 and discovered my XP and Photoshop activation failed, unlike the 2013 version. So,After attempting again to clone I was informed my PC-specific registration at Acronis failed repeatedly to load and that the sale was not on record! They are wholly incompetent and a threat to every computer that has had their program uninstalled and reinstalled due to the above failure.

  • john - INCREASED MY BLOOD PRESSURE!!!!!!!

    After reading all the positive reviews this received I decided to go to GNC and buy this product. I paid $99 for 1 60 capsule bottle. Been taking it for a week now. I am a 40 year old athletic built guy who exercises about 4 days a week for about 2 to 2 and a half hours a day. The good: makes you feel great. All kinds of energy. No excess heart rate. Not jittery. No nausea. The BAD: raised my blood pressure from my normal 110 over 80 to 170 over 108. Very dangerous BP. I ADVISE ANYONE TAKING THIS TO MONITOR YOUR BLOOD PRESSURE. I COULD HAVE HAD A STROKE. I will be returning this to GNC.