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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Lily Sanderson - Perfect caffeine source!

    So I was a little skeptical trying pureLYFT because the price seemed kind of high, but then I thought about how much I pay for a cup of coffee and it did not seem that bad! I personally do not like the taste of black coffee or the fact that it stains my teeth and causes, ehem, problems during the digestion process, so this was a good alternative for me.

  • Amazon Customer - A disappointment

    It may be the most popular, but I found it not to be well laid out and not well indexed. It was not particularly useful. The typeface is very small. I left it in the room I rented in Iceland, no interest in picking it up again or even passing along to a friend.

  • Mecha Becca - I love unicorns and the unicorn emoji is in my top ...

    I. Am. OBSESSED this this!!! I love unicorns and the unicorn emoji is in my top 3 used emojis. I'm also a summer type of gal, so this pool float was an OBVIOUS but for me. It is made of thick plastic so I'm not super concerned with holes and I know how to patch it in case that does happen. The colors are bright and the design is super cute. I want to buy like 6 more!