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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Cara Downing - Horrible, defective, dangerous!

    I have been using these diapers since December 2014 and I have loved them until this month's delivery. I recommended them as the "holy grail" diaper to all my friends and family with infants. We got our box of diapers like usual last week and since then we have had nonstop problems with the diapers. They have been tearing and ripping apart, and worse - this morning we woke up to our son rolling around in gel material in his crib and found out that the diaper had actually exploded and all the absorbent material inside had blasted all over our son's clothing and bedding. It was a horrible mess and super dangerous. We are lucky that we got up right before he did or he could have eaten that!! BEWARE, DO NOT USE THESE DIAPERS FROM AMAZON!!! THEY ARE DANGEROUS!! Do yourself and your family a huge favor and don't buy these diapers. We got the Costco Size 4 diapers and they are AWESOME in comparison. Shame on you Pampers!!

  • K Jinks - That was not convenient for me without a smart phone, so I'm driving with the cracked one

    I received these quickly, but one was cracked. My husband put it on anyway because he didn't want me driving with one missing. I call company to complain about the broken hubcap. They told me they would need a picture. That was not convenient for me without a smart phone, so I'm driving with the cracked one, I guess for he price I paid I shouldn't be surprised. Still disappointed.

  • BenBB - Invaluable

    Married guys, do yourself a huge favor and stop reading these reviews and/or shopping other similar titles. BUY THIS BOOK RIGHT NOW. This is as close as you're going to get to an operator's manual for your wife. Get it. Remember all those little suspicions you had about your wife over the years, all the subtleties you noticed, every single epiphany you ever had about how sex and marriage really work and SHOULD play out? The author, Athol Kay, lays them all out in humorous, sometimes painfully obvious, terms and gives you every tool and technique you need to get the most out of yourself AND your wife. Don't waste any more time, just read it and you will finally understand.

  • Drizzt's Pen - Incredibly gripping conclusion to the current series! I can't recommend it enough!

    Awesome and gripping. I typically don't do reviews but I have in this case. Daniel Arenson just became one of my top 3 authors. The invasion of Abaddon begins, will anyone survive? Suspenseful and gripping.