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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • C.J×3 - Very impressed and make our house look really good at night

    Wow! I bought and some solar lights before but they were cheaper ones and broke. These are soo worth the money they are some of the nicest well built solar lights I've honestly seen. They are heavy duty and not made cheap. Also they have a on and off button and a backup battery in there. Thats a really nice extra because usually most dont have that feature and when they do they make you buy the battery. Very impressed and make our house look really good at night! My husband was really excited to.

  • TSRace - Great deal and doesn't smell bad like other reviews

    Got this for mother as a gift. She had been looking at them but was concerned about posts about smell. I ordered and checked the box when it arrived. There wasn't the strong bad smell others posted about. I am not the user but having shopped looking for one of these I would say this was a great deal