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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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Excellent set of wrenches with most commonly used sizes and convenient storage pouch to keep them organized. The only problem I have with the set is it didn't come with the 9/16", in it's place is a 5/8" wrench for a total of two 5/8" wrenches. Fortunately I haven't needed the 9/16" as of yet as my vehicles use metric sized bolts and nuts.
I, too, was hit by a very pushy but incredibly charismatic salesman at a mall kiosk. The price went from $120, to half off, then down to 40 and I walked away. I took it home for $25 when he came back for me ;) In any event, I used this last night on my poor change in weather, kinda flaky, dull looking skin. I was a bit skeptical but hopeful. Wow! I was seriously impressed. Followed up with my own skin moisturizer and my skin felt new! Soft, smooth, flake free and radiant. I intend to continue using this product but next time I'll purchase through Amazon so I don't have to go through the whole sales push.
Nice full set of wrenches. Only problem was the set was not new in box. Was opened and gently used. Worst wear was on the carrier case. Going to get used anyway just wished they were labled as used-like new.