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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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I bought these from Derby cycles through amazon and wasn't very happy with the color in person tried to see if I could exchange them and Derby Cycles was not very good to deal with they wouldn't even speak to me although Amazon was outstanding they took care of my issue and stood behind me. I would not recommend buying anything from Derby Cycles but I would recommend Amazon…. as for the gloves they are nice gloves fit comfortably and seem to be well made, I've only used them a couple of times but would like to have a different color.
Very disappointing. This insert is well enough constructed, but the design is weird, making it impossible to get to your camera or lenses quickly. You must remove the insert, really, to get at your equipment, which defeats the protective purpose. I recommend shopping for a different insert from another company.