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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
Graduate Medical Education Program | Riverside Community Hospital - At Riverside Community Hospital, we're committed to a vision of world-class academic residency provided at a state-of-the-art community hospital located in beautiful Riverside, California.
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Do not buy this harmful product !!! I bought this product a few weeks ago for my 14 yr old indoor cat who had been scratching a lot. Topical flea products are a pain with the oily mess and having to remember the monthly dose, so I thought this would be great. Product packaging states that mild skin irritation is possible and will pass. Three weeks in, and she has huge bald patches around her neck, with scabs and weeping sores, all directly in a ring around/under the collar. She has also been very tired and lethargic, has lost weight, and been vomiting clear fluid, which is very unusual for her. I will be contacting Bayer for a refund. I have read MANY reviews from other pet owners, both cat and dog, with similar experiences, and many worse ones (seizures, etc.) Please help spread awareness that this product can harm or even possibly kill your fur babies!!!