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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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Great if you are trying to figure out which medical schools to apply to. It was exactly what I needed.
While I admire the reviewers who write detailed book reviews, I'm too impatient to start reading the next book to write my own detailed report (and probably would not be adding anything that hasn't already been said) BUT, I also rely on the reviews to help decide which books to read so feel it's only fair to get my 5 stars included in the numbers. I thought it was a great suspense novel with just the right amout of romance/smut :) My only negative comment is while reading this on a kindle, there was no page break, font change or anything to note that you were now reading from another character's perspective. Granted, it only took a few sentences to realize you were no reading from the killer's perspective vs. Lacey', etc, but I feel like it would have been something very simple to add a page break, a row of ********, or a header LACEY when it switches. That said, I've already bought and started the 2nd in the series so this is clearly a minor annoyance and didn't affect my overall impression or enjoyment of the book
It is a very good resource Bible. I'm using it in a Bible Study class and it is a great help in understanding scripture. I had a little trouble navigating at times but I appreciate the additional perspective not provided my other Bibles, both Kindle and paper.