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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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    Country: 194.110.77.227, Europe, PL

    City: 21.0362 , Poland

  • J. Ellen - LOVE IT!

    Love it! Love it! Love it! So easy to handle, lightweight, and the battery lasts long enough for my entire yard. A second battery was very pricey, so for another $45 I was able to purchase another trimmer! So now I have two batteries and two trimmers. I also have the blower which is another awesome tool.

  • Lisa - Unpleasant sent

    I peronally don't like the sent of this. I can still smell it in the bathroom hours later. I thought i would be a mild sent since it is for babies but its not. The only reason I am not giving it a lower rating is because it seemed to do its job.

  • Kristen Prime - awful

    difficult to learn how to use, once i did learn the curls didn't hold more than 30seconds and they weren't the curls I expected. I would rather use a wand or curling iron to not want to break this tyme iron in half for how frustrating it is to try and use.

  • Angela Patterson - Omelette bowl - amazing!

    Love this bowl! I emailed Joseph Joseph & in fact, you can use this for 1000 watt microwave & it will work perfectly, just adjust timing. My first try, I did one minute. I may take off 10 seconds though & see what difference that makes. Omelette was delicious & cooked thoroughly (I used two eggs, shredded cheese & bacon).

  • K. Allenby - Amazing.

    Just when I thought Golden Czermak couldn't do anything more to upset me, he goes and CRUSHES that belief. Made To Suffer is a genious title. When settling down to read this book make sure you have whatever comforts you need..alcohol, chocolate, a cuddly toy (and kleenex lol). I'm not joking, this book is going to push your limits of how much heartbreak you can handle, in the best way possible, of course.

  • Herman Natanblut - Has a good ride and good gas mileage

    Has been very reliable. Has a good ride and good gas mileage.Only have 48K miles so it really has not been tested.