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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • WireInspired - Hope in a box

    For anyone who is losing their hair, this product is intended as a DIY alternative to costly pro laser treatments. The packaging is discreet, and protective of the contents. The product itself is well made. Does it work? Well, I'll reserve judgment for another 30 days, as it takes at least 60 days to see results.

  • Jennifermon - Perfect for camping and power outages.

    Great product. Has a great battery life for use for several days. I love the fact that you can charge your electronics if they are running low. Very bright light. Wish I had another one. I received this product for free or at a discount in exchange for an honest unbiased review.

  • T. Priest - Great for our baby

    Our little one was having some diarrhea issues that were ongoing and unexplained. She is exclusively breastfed and no formula or other foods yet. Our pediatrician recommended trying probiotics so we ordered these. Within two or three days her stool was the normal look and consistency for that of a breastfed baby. I am so happy and relieved. The dropper is glass and has the line for the dose which makes it super easy. You have to make sure you shake it well, but baby isn't bothered by taking it.