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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

Weather for Local and International Locations - AccuWeather.com - Get local hourly, 10 day and 15 day weather forecasts for over 3.5 million locations worldwide from AccuWeather.com. Access up to the minute weather reports, radar, maps and video to help you plan your day.

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  • Lane R. Hatcher - I will never buy another book of recipes on Kindle ...

    I will never buy another book of recipes on Kindle unless I can see at least the names of the recipes, and some idea of what kind of ingredients we're talking about. Even at a bookstore I can open the book and see a REAL preview. Kindle -- up the game by letting me see what I'm actually buying, and enough of the "first chapter" thing, that doesn't help me at all. Sorry, Alton, no go.

  • AJ in DC - Great toothpaste overall - great whitening too!

    Great toothpaste and whitening kit. I meant to order the larger size but accidentally ordered the 1.2/1.4 oz set. I will use these for travel, no problem. I have porcelain crowns on top two front teeth and love how gentle Supersmile is on both my teeth and dental work. I noticed whitening from the first use and think it keeps getting lighter over time very subtly but noticeably. I love this toothpaste.

  • Amazon Customer - This show is hilarious and serious all at the same ...

    This show is hilarious and serious all at the same time. Look forward to watching the next episode every week