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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Kenny D. - A must have

    This a J. Coles best album to date. Conceptually very clear, message and topic management or content is tremendous. He also has grown so much lyrically and is definitely in the conversation of best Mcees out today.

  • JSWilson - Word for Mac 2011 is really bad

    This product is truly unstable and deficient in capabilities. If I were a Mac user I would stay away from all Microsoft products based on my experience with Word for Mac 2011. However, I use Word on the PC all the time so I can only surmise that this was done out of spite.

  • Dare - Not bad.

    Not a bad soccer game. the pitch graphics doesn't look so good. player movement is great. still not enough licensed teams.

  • Ashley L. - Great gel cleanser, but doesn't foam (if that's what you like)

    I love the Stone Crop line and the way it smells! If you are used to organic products, you will appreciate the smell of this. I love that it doesn't dry my skin out at all. The only reason why I have it 4 stars instead of 5 is because I was expecting it to foam a little more. I like my face to feel squeaky clean. I don't doubt that this cleans my face, but it is not that squeaky clean feeling that I am used to with my previous cleansers.

  • John Hollingsworth - Best tax book now in ebook format

    I have bought this tax book almost every year so I have quite a few on my bookshelf. It is great that it now comes in an easily searchable ebook format. I was able to answer my tax questions even faster.