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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • K. Yee - AAA rating from Moody's

    I was looking into these for upgrading my a/v system, and found a review of these in the Spring 2008 issue of Moody's Audio and Mortgage-Backed Securities. These have received Moody's highest rating, AAA!! The system they used to test these based on a Lehman Brothers' amplifier with a Bear-Sterns pre-amp and AIG speakers. It turns out that if you leverage these cable 30x, there's no problem at all. They *are* AAA rated after all.

  • Sherry Pilkington - This is a very good value for the money

    This is a very good value for the money....I wish they had the abbreviations for transactions like the ones I get when I order checks, but they are very good....

  • Debra - Satisfied

    They are similar to my Original Apple Charger, works great. I bought a lot for my family and friends, they are very satisfied with it. Definitely worth paying this product.

  • Eric J Antonik - so I wanted to thin the product out so as not to kill the only 3 nice size goldfish in my pond

    I have a pond about 30' x 50', maybe 10ft deep in one area. Had a major problem with an invasive pond weed. I've tried to look online to find out exactly what it is, and I believe it's the chara plant. I ripped a bunch of it out at the beginning of this season and it grew back ten fold. I decided on this product. In a chemical sprayer I split it 3 to 1. 1 part product, 3 parts water. My pond has a natural spring that feeds it, but it doesn't flow constantly, so I wanted to thin the product out so as not to kill the only 3 nice size goldfish in my pond. I know the product says "not for goldfish" but oh well. They were $0.30 goldfish...(but they're about 5" long now.)