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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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Country: 31.170.167.155, North America, US
City: -97.822 , United States
Giving this 5 stars for now....I plan on using it for 4 months and at the end of that time, will be prepared to give a well informed review based on my experience....I'm going to update this review once a month.
I have multiple sensitivities to fragrances and chemicals, so when I saw this shampoo I thought that since it was for babies, it'd be fine for me. However, I am SO allergic to this shampoo I can't imagine how anyone is using this on an infant. Even my boyfriend, who isn't allergic to anything like this used it once in a pinch and his eyes were burning. The smell is so strong it permeates my hair and pillows for days if I wash my hair before bed. If I just rinse my hair with water after a workout, the smell comes back and practically chokes me to death. My nose runs the entire day, I get a pounding headache, and I sneeze constantly when I use this. My entire apartment reeks of this stuff even if i just use a dime sized drop. Even writing this dramatic review (I know it's pretty dramatic) I remember what it smells, just awful. I was surprised because I use other Burts Bees products just fine, including their Ginger and Citrus body wash, which don't cause me any problems. I'm guessing that there must be some "approved" awful chemical in here that people haven't freaked out about yet, therefore they can get away with putting it in the shampoo/soap. There is nothing natural about how this smells or even it's texture, so I'm going back to making my own shampoo with Bronners soap or finding a new shampoo that won't give me a full blown asthma attack. Seriously! If you're using this on your baby, I'd seriously reconsider.
This cube is absolutely outstanding it's anti pop mechanism is wonderful it is fluid and effortless it is very smooth cube that leaving the cube 5 stars