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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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Out of all the rule books I've ever fallen asleep and drooled on at at 4:32 in the morning this is easily one of the best. The pages function like a soft, fluffy pillow and the cover is nice and absorbent of any residual drool or coffee. My only critique is that I could have done without the pages being covered in cloraform, as passing out violently every time I try to read a rule isn't that helpful. Lastly, a giant pillow on the cover would help as well.
This is a great product. Had a little problem getting to the one connector in my ford edge, but after some contortions of my hands, and help from a guy who used to install dashes for a living, the installation was easy. Set up was simple. Watched the videos on line and unit was up in running in less than 5 minutes after install. I can't say anything bad about this unit at all. I'm very happy to get into a cool car in the summer and will be even happier to not have to go out and start my car in the cold mornings.
I made this purchase based on the many positive reviews I found and because my hair breaks easily. Have tried out other products in the past and try to stick with them for a good period of time in order to give them a chance to do their thing. This one I only used for a short period of time, about a week, and after that I used it on a few scattered occasions until I realized it was a bad product choice for me. Initially I suspected an increase in hair loss/breakage (I couldn't figure which) but thought it might be my imagination and gave it a few more days. Nothing changed...I'd be walking around in short-sleeves and pretty regularly through the day would feel a tickle on an arm, look down, and see a hair laying there. It was happening too frequently for me to feel good about this product, and it was the only styling aid other than shampoo and conditioner that I used. Even when I stopped using it regularly and started using it sporadically, the same thing was happening on the days that I used the product. I admit that I'm normally aware of some hair shedding, but the rate seemed to accelerate with the Mane 'n Tail so had to can it.
So glad we didn't buy this crap. We were >this < close, and I came here to check the reviews - thank you to everyone who took the time to write a review! I'll stick to Kaboom & Clorox with Oxi for my toilets, tile, & porcelain.