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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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Country: 95.46.98.68, Europe, UA
City: 34.1372 Dnipropetrovska Oblast', Ukraine
Amazing after-taste. A hint of lemon. More hint of chocolate. Sweet, enticing aroma. Delicately distinguished coffee flavor. What more can anybody ask for from this damn good coffee? MORE FREAKING STOCK!
This is a durable hiking pole! After it arrived, we promptly gave it a test walking around the block. With it fully folded up, it was actually the perfect size for my son who is 3. I may have to battle him to be able to use it--he loved it! It was so cute seeing him walk around with it, "hiking" right beside me. In its extended positions, it works easily for both myself (5'6") and husband (6'2"). I'd purchase again. This arrived quickly with prime shipping and was well packaged. In order to save time and money, I do as much of my shopping online as possible. With two young children, I don't have time to head out to multiple stores in order to find what we are looking for. It is so wonderful to find this product online so I don't have to go out hunting. I always do quite a bit of research on Amazon, relying on other people’s reviews when making decisions about what products to purchase since there are so many available. In the end, I have more time with my family and am able to find a well-reviewed and researched product! That way I can be sure what I do purchase will last and function well and not leave me going back to the store or Amazon to replace soon after. I do think it is fun to test products, but I have to admit that I am fairly opinionated and don't hesitate to critique products for their short fallings or to rate items low when they deserve it. All opinions are my own! Please note: I have purchased this at a discount or for free in exchange for an honest and unbiased review. If you find this review helpful, it would be great if you would click the "helpful" button below! Thanks!