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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • sgolas - Weight

    I have been taking it but have not lost any weight. I have noticed my appetite decreasing but no weight loss.

  • SNC Colorado Springs - Buyer Beware

    When you sign up for Enhance Payroll with unlimited employees, there is $2.00 fee per employee / per month. For us, that means that we are paying an additional $30.00 per month on average. I will go a different direction next year. For now, I am stuck with this. I'm feeling a little misled and the information was not documented anywhere visible.

  • Rollie D. Newton - The software is easy to use, but it won't let me e-file.

    I am retired and have HSA savings. There is a glitch in the H&R Block program this year that keeps you from e-filing your returns if you don't have a high deductible insurance plan, but do have a HSA account that you used to pay medical expenses. I contacted H&R Block twice and was finally told that even though my tax returns looked fine, I would have to print and mail in my federal and state returns. So my five free e-files got reduced to zero. Last year I had the same situation with the HSA, but I had no problem with the e-files.

  • Alex N - I do not recommend this case for the Iphone 6s Plus.

    I ordered this case because I love how the case looks and it had excellent reviews. I read that it was compatible with both the Iphone 6 and 6s Plus so I went for it. However, I have to say that it is not a comfortable fit at all for the Iphone 6s Plus. This is because the 6s Plus has slightly larger measurements. This causes this case to be extremely hard to put on and take off. The 6s Plus fits so tight that it made me uncomfortable in the event I dropped it because the case felt like it was being stretched out way too much. It also managed to chip a piece of the paint on the side of the phone while I was taking off the case. So I went ahead and tested it on my friend's Iphone 6 Plus and it fit so perfectly on his phone as well as being easy to take on and off. I have read that there are a lot of phone cases that are not compatible with both the 6 Plus and 6s Plus even though the manufacturer states that in fact they are compatible, and this UAG case is one of them in my opinion.

  • H. Kilmer - Caviat emptor

    This mat smells horrible. If this is non-toxic, I would be truly confounded. It does what I need it to do, but there is no way I would ever buy another. I wish I would have spent a little extra to get a mat that didn't smell like skunky plastic.