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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • ereripancake - Good product

    This was a great product that I would buy again. It was very durable and fit perfectly!!! This product saved my phone from shattering when I accidentally dropped it the other day. I, personally, would recommend this product and buy again!! I was given this item for free in exchange for my honest review.

  • J. Hawks - Excellent stroller

    The Vista is an excellent choice. It is versatile, light (for a full size stroller) and resilient. We live in downtown Chicago and take it everywhere. It withstands the uneven sidewalks, snow and ice, salt and potholes. The redesigned two button folding feature makes it very easy to fold and store as well. There is a lot of storage and an endless supply of accessories from UPPAbaby, among others.

  • Kit Ebert - Very disappointed, this product is frustrating to use and loaded with quirks

    I have to say, I am very disappointed in this product. First of all, when I downloaded the gedcom file from ancestry.com to the home pc software, the current/living generations had the second marriages and kids assigned to different people and was very frustrating to fix those issues. The printing option had several errors when selecting a page size, it would be nice if they listed the paper measurements (inches and metric) instead of tabloid-A3-A4-Legal-etc. When printing, the font sizes should allow smaller font, the page borders had print errors when the actual page was printed, when 5 or more generations were printed on 11x17 paper there were some people missing on the page. The software should have a syncronization (up/down load) feature to allow both online and home trees to be updated. Saving and copying media files from other public trees are difficult and cumbersome. I could go on and on about issues and things I expected a higher end family tree software to have.