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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Amazon Customer - This was a really great read. Some people criticize the lack of professionalism ...

    This was a really great read. Some people criticize the lack of professionalism in the characters considering that they're scientists, but I think it makes sense given the circumstances (I won't spoil the book for this reading this review). I think this book is a breath of fresh air for the sci-fi genre and I can't wait for the next one to come out.

  • Daniel Duran - PD32 vs PD32UE

    I have the PD32 and after hearing of the next, new, latest and greatest PD32UE, I had to buy one for myself because I love my PD32 so much. I am having a hard time choosing which one I prefer though. The one thing I've about my original is that it has more of a narrow beam and throw than the UE. They have their tradeoffs, while the UE is brighter and offers an extra brightness mode and some length, it just doesn't throw those 740 lumens as far as the my original's 340 lumens, but it does flood more which could be a good thing depending on the situation. Don't get me wrong though, I love both these flashlights and will not dismiss them for anything because there is nothing wrong with either, I'm just glad to have the best of both worlds.

  • Bonnie - Love our Clek!

    In terms of safety, we feel that this is the Rolls Royce of all car seats. It's very solid, durable, and secure. It took longer to install than our previous car seat, but it wasn't difficult to do by any means. My only complaints are, that at the price that you pay, it should have better shoulder straps and have an included cup holder. The shoulder straps are quite small and the Velcro scratches my daughter's skin. I would also love it if the seat cover was machine washable.

  • Jennifer Toro - I am sort of new to the world of essential ...

    I am sort of new to the world of essential oils. I opened the package and you could immediately smell the different scents. A few drops in a diffuser is plenty otherwise it is a little overpowering.