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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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I enjoyed the subject matter immensely, and would have given five stars but for less than stellar editing. I am an avid reader and reading is one of my greatest pleasures. I also have a love of well-written works, which, for me, consistent of good grammar and editing as well as a good storyline. Having said this, I do recommend this book because the story of the life of Owen Tudor is well worth reading, and the author did well in his research and laying out an engaging, interesting story.
I need 5 pounds of gummy peaches. And you just might, too. Truth be told, I bought these so that I could qualify for Super Saver Shipping. It seemed like a good idea at the time. Now it's a month later and I still have a ton of the greatest gummy peaches on earth, and I still think it was a good idea.
It did the trick but a chunk of skin on the bottom of my foot came with the corn the size of the cushion... Didn't hurt but only took one of the pack of 8 to do it. So you will have extras.