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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Amazon Customer - Too stealthy and compact for its own good! Lacks passive data reporting

    I purchased two to allow the swimming and other dual tracking activities and while the device is working well so far, on its first outing the second device slipped out of its strap and was lost along the trail.

  • Lord Cthulhu - Awesome calendar, but....

    You would have to be mentally retarded to pay what these sellers want for a CALENDAR. It tells you the day of the week. It doesn't make breakfast or wipe your butt. It doesn't clean your house or drain your rod. IT's A FREAKING CALENDAR! If you have extra money to burn, I know a prince in Nairobi that needs your help!

  • FS Mason - Looks really good!

    Read the directions and don't over sand, but it came out real nice. The main reason the folks rented our house according to them. 2-1/2 years later it had very little wear. Very durable. It does take some time in install, but okay for a DIY.

  • Maezeppa - Lasts at Least 18 Months in the Refrigerator

    Sugru is bang-on great. Just make sure you don't try shortcuts like skipping over ensuring surfaces are clean and oil-free, or not kneading the Sugru for a while to make sure it's fully consistent.