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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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    Country: 194.110.77.227, Europe, PL

    City: 21.0362 , Poland

  • Taylor - We love this stroller

    We love this stroller. From its function, to its finishes, to its self standing ability, this is perfect for the city mom. The added bassinet was a great place to sleep when our little guy was first born. Couldn't be happier.

  • Alan Schuler - Terrific Upgrade

    Perfect fit. Looks better than original and works as well, if not better. Highly recommended. I have 2 Minis and this is on each of them.

  • P. McKenzie - Natural Tick Repellant

    30 years ago, my sister competed with her quarter horse in Versailles, Missouri in competitive trail rides. Riders and their horses were coming in loaded with ticks after each days ride. Neither I nor my sister had any ticks and Ranger only had two because we bathed with Basic H and she washed Ranger with it as well. Highly recommend it.